Syn-Coll (Palmitoyl Tripeptide-5) Peptide Syn-Coll, otherwise known as Palmitoyl Tripeptide-5 or Tripeptide-5 , is a synthetic peptide that click here was developed to enhance the production of type I collagen. It appears to repair damages caused by photo-aging, and Syn-Coll has also been suggested to support the regeneration of skin protein production, such as elastin or collagen. Syn-Coll (Palmitoyl Tripeptide-5) is the synthetic equivalent of Thrombospondin 1 (TSP-1).